TYLENOL ® is safe and effective when used as directed. The safety of TYLENOL ® at recommended doses has been established through 50 years of use and scientific investigation. Taking more than 3,000 grams in a day can highly increase the risk of hepatotoxiity or also known as liver injury. Liver damage can occur by taking high doses of Tylenol (Acetaminophen) or if a. Use Only as Directed About 150 Americans a year die by accidentally taking too much acetaminophen, the active ingredient in Tylenol. The toll does not have to be so high. Acetaminophen is the generic name for Tylenol, a pain reliever and fever reducer. It's one of the most widely used pain medications in the world. Tylenol (acetaminophen) is a pain reliever and a fever reducer. Tylenol is used to treat many conditions such as headache, muscle aches, arthritis, backache, toothaches, colds, and fevers. SHOULD I TAKE TYLENOL, ADVIL OR ASPIRIN? by eugeneyeung. When I work as a pharmacist in a retail pharmacy, I get a lot of questions from customers on which painkiller is best for them. I took the generic brand but the label still said cannot take more than 2 in less than 24 hours. I shoulda known but my migraine was coming back so i took more. You can take both together, as they both perform different functions. There should be no side effects, given you have no side effects from either individually. I am totally amazed at the speed of relief of the new Micro Laser Drilled Tylenol. It works as advertised at the Speed of Life , I have consistently found it to be affecting the pain within 3 minutes of taking the medication. Yesterday I purchased Tylenol arthritis.I have been taking perscription antiflammitories for years. My issue with inflammatory medication is does nothing for pain in my case anyways.